The hormone treatment should be cautious don't let breast cancer take a fancy to you

The hormone treatment should be cautious, don't let breast cancer take a fancy to you
The hormone treatment should be cautious, don't let breast cancer take a fancy to you
A few days ago, published two reports finished by American and Austrian researcher respectively on Britain's scientific magazine " Nature ", they study independently but has obtained unanimous result, namely contraceptive and hormone substitute estrogen, progestogen in the treatment and get in touch closely through broken bone cell factor and breast cancer of splitting up. This magazine also published a discovery of the researchers of cancer of Princess Margaret Hospital of Hong Kong before, indicate ovarian hormone progesterone has born the important role in changing the stem cell of mammary gland. Artificial synthesis progestogen used in the contraceptive course blindly cause the morbidity of breast cancer to rise " to use the hormone treatment on earth? The daughter says recently my temper is more and more discredited, I suspect whether oneself is to climacteric too, friend say go hospital turn on, supplement estrogen just by some medicine, but I surf the Net consult, it say someone breast cancer it can bring out treatment hormone,say someone can,there is be a lot of evidence behind, who should believe? " Ms. Song says disconsolately. Compare abroad, because the proportions of personnel of regarding hormone as the means of improving looks etc. at home are relatively low, so find data correlated to breast cancer are changed will be less. It is reported, involutional women are in the body progestogen drops, estrogen rises, mostly adopt hormone to treat in place of the treatment, the increasingly many data make such a crowd of Ms. Song at a loss. And the recent report says especially, the hormone, will all be through RANKL (the factor of splitting up of broken bone cell) Get in touch with breast cancer closely, is that really like this? Progestogen " Instigate " RANKL " gives a piece of bad advice " "If the family has rheumatic arthritis or osteoporosis patients, must have heard the name of RANKL, traditional Chinese and western medicine will mention, what a lot of people do not know is, it is closely related to development of mammary gland. " The teacher-training university students in the capital order endocrine beautiful duckweed associate professor Yang of research room of scientific institute's reproduction to explain, RANKL is a kind of protein existing in the skeleton, are called factor of splitting up of the broken bone cell, express and become abnormal or cross and express, can cause a series of bone disease, such as causing osseously to run off to cause osteoporosis, will also cause rheumatic arthritis, the ill arthritis of silver bits. Ever domestic someone has studied, find if the mouse during gestation lacks RANKL, then the mouse can't secrete the milk. "But is not clear what kind a mechanism RANKL is specifically with the growth of breast cancer cells in. " Yang XiuPing says to the reporter. Beautiful duckweed Yang explain, these two different laboratories find respectively RANKL express in the mammary gland cells of the mouse too, control the morbidity that induces breast cancer produced from progesterone after explaining RANKL. Among them, the scientific research personnel of Austria are injecting sex hormone MPA (author's note for mice: A common medicine, includes progesterone of artificial synthesis) And then, find RANKL expressing amount in mouse's body increases, the mammary gland cell " crazy " Expand team, until the stem cell in the leather cells drives to stand up on the mammary gland in the the dormancy, then the mouse suffers from breast cancer. In order to verify one's own idea, this laboratory has dealt with the little mouse through a certain genetic means, make because RANKL of they in the body lose a certain " Help " Can't bring into normal play function, inject and then progesterone of the artificial synthesis at this time, find mammary gland cell increase, see either the stem cell in leather cells has " sound " on mammary gland ,The morbidity of breast cancer is reduced greatly. Meanwhile, a group of researchers of U.S.A. tested that can inhibit a medicine of RANKL function from preventing and curing the result of breast cancer. E, under the carcinogenic environment equally, reduced after taking the morbidity of mouse's breast cancer of experiment of the relevant medicine, the transformation proportion of lung cancer drops to some extent too. Outside hormone cause the intersection of breast cancer and morbidity rise beautiful duckweed Yang say, " put forward RANKL hypothesis correlated to breast cancer on someone more than ten years ago, establishing the system of this set of mice nearly spends a generation of scientists and 10 solid years' time too. " It is reported, a lot of women have accepted and dealt with involutional hormone in place of the treatment or used contraceptives blindly, progestogen of artificial synthesis used in this course has led to the fact the morbidity of breast cancer rises. "One's own progestogen, estrogen content in the human body are by microgram, and the external condition such as estrogen content of urgent contraceptive is counted with milligram, in this way, will destroy the equilibrium of levels of internal hormone. " Yang is beautiful the duckweed is added, "this finds that very meaningful, can consider regarding RANKL as one to prevent breast cancer from taking place or prevent the medicine target used for preventing, treating in early days from clicking in further research work, certainly, this needs to consider mouse and human kind difference, and the variety of breast cancer, not all breast cancer are brought out by progesterone. " And these two item conclusion too and early before echo one of researches published in " the Nature ", when progesterone in mouse's body secretes peaking, stem cell and neighbouring cell begin to be exchanged mammary gland each other, drive the normal stem cell's quantity of mammary gland to amplify, the environment that this kind of activation mechanism brings changes to make breast cancer apt to take place. It is reported, this kind includes RANKL and inhibits the medicine of the factor from carrying on the clinical trial, except being regarded as a lost therapeutic method of bone in osteoporosis, it turn into and can treat the medicine of breast cancer in the near future also expected. Take hormone, should be cautious "All the intersection of contraceptive and principal ingredients leave two kinds of materials: Estrogen and progestogen, with lying in two kinds of component ratio are different. " Yang XiuPing introduces, estrogen, progestogen and androgen are called sex hormone jointly, namely hormone. When women's endocrine is insufficient, will often choose to take the medicine containing these three kinds of materials, such as the substituting treatment, in order to set up normal menstrual cycle and ovulate. When taking the sex hormone medicine and is lower than certain content, what it played is facilitation, if higher than certain content, the result completely contradicts, it was inhibitory activity that was played. And the high estrogen content by milligram of contraceptive utilizes this to reach the contraception result, it is reported, the hormone content under human body's physiological state is counted with microgram. "Urgent contraceptive, in order to helps meet an urgent need, but the dosage that the content of progestogen of urgent contraceptive is equivalent to 6 slices of regular contraceptives after a scene of things, will bring the content of progestogen in the human body up to the sixfold equivalent to the normal level quickly first, then fall to and well below the normal level suddenly. " Beautiful duckweed Yang explain, when it is well below the normal level that progestogen drops to, membrane get support of progestogen, loss, bleed in the uterus, thus make embryo unable, wear bed, miscarry small in other words. So propose using compoundly and avoiding Pregnant medicine, the better one uses contraception ways for external use such as the sheath,etc.. Does but a long-term research to 46000 women in Britain find, can contraceptive increase slightly? Olive Qi Man blink �� shellfish duckweed �� Yu is stupid to last Kou �� quail olive and overstep the authority and ancient vessel Yun of Quan 1 �� last �� * bucktooths mediocres fierce and last arm after living abroad to �� torrs of fish hawk after engraving on gold or silver in purine in �> �� of duckweed of �� s abundant �? ----It is chained that relevant - ---Hormone raised the fatal rate of breast cancer a few days ago in place of the new fault of the treatment, U.S.A.'s medical association's periodical was released one substituted the new fault of the treatment about hormone: What the hopeless menstrual woman adopted especially estrogen and substituting treatment that the progesterone works along both lines, not only will increase and is cured women and suffer from the risk of breast cancer but also raised the fatal rate of breast cancer. Over 16500 menopausal women have participated in the health and proposed the activity, they or accepting hormone substitute the treatment, or took placeboes, this activity was stopped in 2002. 3 years later, subsequent researchers find, hormone that they took will increase and suffer from the risk of breast cancer, apoplexy, heart disease and pulmonary embolism. Research points out, use Prempro (author's note: Ath common hormone substitutes prescribed medicine, contains the estrogen and progesterone) Woman easily suffer from diffusion breast cancer: 0.42% that it is accepted that hormone substitutes the women of the treatment are diagnosed the cancer, and the placebo control group is 0.34%. In suffering from the women of breast cancer, accept hormone in place of developing into the lymph gland (breast cancer marks in later period) of the treatment Possibility high (23.7%) ,The placebo control group is 16.2%. And compare with women not taking this medicine, suffer from breast cancer and accept the possibility of other reasons is higher after hormone is died from cancer or made a definite diagnosis of the women of the treatment. Do not totally know the impact on cancer severity or mortality of this medicine way at present, but already indicating the hormone treatment can make the breast organize the density to be large before this, therefore it is more difficult to cause tumour in the breast X-ray photo to find, thus delay diagnosing. In addition, estrogen hormone will also promote the growth of the particular breast tumour or make it spread with higher speed. Medical professor Brigham, Women's Hospital Professor JoAnn.E.Manson of Harvard Medical School have talked about, women should not take hormone at all, unless they need until should to intermediate symptom serious really, perplex sleep and it influences theys to be hectic and night sweating etc. in quality of the life seriously. (Jiang HongTao)


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