Influenza virus " Polymerase " Analysed and explained

Influenza virus " Polymerase " Analysed and explained
Influenza virus " Polymerase " Analysed and explained
According to the report of Tokyo (Xinhua) the 30th July ' Reporter Qian Zheng) A few days ago, Japanese scientist analysed and explained the ribonucleic acid of influenza virus polymerase sub-units and combined the structure in the position, have offered the new thinking for developing vaccine of influenza. Japanese high-energy accelerator research institution publishes the press Communique and says, ribonucleic acid of the first type influenza H1N1 inferior type virus polymerase is made up of 3 sub-units, any sub-unit disappearance among them, ribonucleic acid playing a key role while influenza virus duplicate polymerase is unable to work. Researcher physical and chemical research institute full-length to radiate the apparatus synchronously through high-energy the intersection of accelerator and research institution and Japan, have analyzed " PA " in 3 sub-units With " PB " Combine the structure of the position between two sub-units. Researchers find, these two sub-units combine essential amino acid residues, and confirm this amino acid residues once morphs, will hinder the combination of two sub-units, the activity of ribonucleic acid of influenza virus polymerase is reduced notably too. The communique says, past influenza vaccine is often only effective to a kind of inferior virus, and influenza virus is very apt to morph, will probably make vaccine just worked out fail rapidly. Structure between the virus ribonucleic acid found this time polymerase sub-units, all applicable to all within many kinds of inferior influenza virus including bird flu virus. This contributes to developing new vaccine, inhibit many kinds of hyperplasia of influenza virus directly through hindering the combination of the sub-unit.


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