Freezing the relevant new gene of disease gradually is found

Freezing the relevant new gene of disease gradually is found
Freezing the relevant new gene of disease gradually is found
According to Xinhua News Agency Beijing ' Reporter the intersection of Zhang Zhong and rosy clouds Ge sweet-smelling autumn) Britain and Australian researcher say on new American Science, they have found a kind of new gene correlated with freezing disease gradually, this will contribute to further finding out about the pathogenesis of such fatal neuronal regression disease of sport. The medical name freezing disease gradually is named the side of amyotrophy to ask for sclerosis, it is unable that clinical manifestation withers gradually for muscles. The patient will breathe but death depletedly finally. This kind of disease is classified as one of five major hopeless case by World Health Organization, famous physicist Hawking suffers from this disease promptly. The scientific research personnel from organizations such as the institute of king of London University,etc. say, in 1993, people have found a variation genetic SOD1 correlated with freezing disease and having illness coming on gradually in family's heredity, but only about 1% of the patients have illness coming on and relate to this. What they found is a gene which is called TDPB this time, it has closer relation with the pathology of freezing disease to make a variation gradually. Scientific research personnel have chosen 154 to suffer from the family and freeze disease gradually, but there is no SOD1 to make a variation the patient of the gene is the research object. The result has found a kind of same base and made a variation on 4 patients of a family among them, on TDPB gene. And take place in freezing disease patient's body gradually in the neuron of pathological change, scientific research personnel find TDP-43 protein of the code forms the group and forms a cluster the form is piled up from behind this genetic mutation. In order to prove whether TDPB genetic mutation relates to the fact that it is not that the family freezes disease gradually, researchers have chosen 200 in Britain and Australia respectively and 172 are not that families freeze a disease patient gradually, check order to its internal TDPB gene. Found finally, the other formal variation of TDPB gene existed in the two human body at least. In more than 1200 healthy body of persons who contrast, no people are discovered and carry the variation of this gene. Christopher of research project director Xiao say, can find same many kinds of variation of gene extremely rare in form. In the experiment, they foster the mutant chicken of internal TDPB gene, find some neurons and other cells of the chicken will die.


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